A challenging entity: multiple sclerosis or collagen tissue disorders: A case series of 6 patients

Authors

  • Chifa Dammak Department of Internal Medicine, Hedi Chaker University Hospital, Sfax-Tunisie
  • Feten Frikha Department of Internal Medicine, Hedi Chaker University Hospital, Sfax-Tunisie
  • Mhiri Chokri Department of Neurology, Habib Bourguiba University Hospital, Sfax-Tunisie.
  • Moez Jallouli Department of Internal Medicine, Hedi Chaker University Hospital, Sfax-Tunisie
  • Mouna Snoussi Department of Internal Medicine, Hedi Chaker University Hospital, Sfax-Tunisie
  • Raida Ben Salah Department of Internal Medicine, Hedi Chaker University Hospital, Sfax-Tunisie
  • Sameh Marzouk Department of Internal Medicine, Hedi Chaker University Hospital, Sfax-Tunisie
  • Yosra Cherif Department of Internal Medicine, Hedi Chaker University Hospital, Sfax-Tunisie
  • Zouhir Bahloul Department of Internal Medicine, Hedi Chaker University Hospital, Sfax-Tunisie
Abstract:

Background: Multiple sclerosis and other demyelinating processes are sometimes difficult to differentiate from the neurological involvement in autoimmune diseases. Distinguishing multiple sclerosis from other lesions due to autoimmune diseases is crucial to avoid unsuitable or delayed treatments. Methods: Charts of 6 patients diagnosed with mimicking multiple sclerosis between 1996 and 2014 were retrospectively assessed. Results: The mean age at diagnosis was 35±7 years. The most commonly neurological manifestation at onset was paraparesis due to transverse myelopathy and uni/bilateral optic neuropathy. All our patients suffered from recurrent episodes of optic neuritis with a mean lag time of 12 months. Other initial presenting neurological manifestations in our patients included ataxic gait and pyramidal syndrome. Systemic symptoms occurred a long time before or after their initial neurological presentation. All patients had numerous T2 hyperintense lesions in the periventricular white matter and spinal cord with contrast enhancement. The antibodies tests revealed the presence of significant amounts of anti-nuclear antibodies. The anti-phospholipid antibodies were negative in all patients. All patients were treated with corticosteroid therapy and neurological features were cleared in all cases. Conclusion: Multiple sclerosis, other myelitis and optic neuritis, are sometimes difficult to differentiate from CNS involvement in autoimmune disease. Indeed, the clinical presentation, immunological profile and MRI lesions may be similar.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

a comparison of linguistic and pragmatic knowledge: a case of iranian learners of english

در این تحقیق دانش زبانشناسی و کاربردشناسی زبان آموزان ایرانی در سطح بالای متوسط مقایسه شد. 50 دانش آموز با سابقه آموزشی مشابه از شش آموزشگاه زبان مختلف در دو آزمون دانش زبانشناسی و آزمون دانش گفتار شناسی زبان انگلیسی شرکت کردند که سوالات هر دو تست توسط محقق تهیه شده بود. همچنین در این تحقیق کارایی کتابهای آموزشی زبان در فراهم آوردن درون داد کافی برای زبان آموزان ایرانی به عنوان هدف جانبی تحقیق ...

15 صفحه اول

Fatigue Severity and Sleep Disorders Among Patients With Multiple Sclerosis: A Cross-sectional Study From Iran

Background: Multiple sclerosis (MS) is the most prevalent autoimmune chronic disease globally. The current study was conducted to determine the relationship between fatigue severity and circadian rhythm sleep disorders among Iranian MS patients.  Methods: The statistical population of this cross-sectional study included MS patients who were members of the MS Association in Khorramabad City, so...

full text

Hydroxychloroquine-induced Unusual Generalized Pustular Cutaneous Reaction As a New Clinical Entity: A Case Series

Background: Pustular Psoriasis (PP) and Acute Generalized Exanthematous Pustulosis (AGEP) clinically resemble each other. There are many patients with generalized pustular presentations like hydroxychloroquine-induced pustular reaction who do not completely fall within PP or AGEP categories and needed to be more evaluated. So we examined a large series of these reactions to hyd...

full text

Bernard-Soulier syndrome or idiopathic thrombocytopenic purpura: A case series

Background: Bernard-Soulier syndrome (BSS) is a rare, autosomal recessive platelet function disorder which is commonly mistaken for idiopathic thrombocytopenic purpura (ITP).The report includes seven cases of BSS that have been diagnosed and treated as ITP for a long time. Methods: Between 2006 and 2016, data of seven BSS patients who have long been diagnosed and treated as ITP were collected ...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 8  issue None

pages  321- 328

publication date 2017-07

By following a journal you will be notified via email when a new issue of this journal is published.

Keywords

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023